许彤辉,博士
教授、博士生导师、实验动物部PI
地址:上海东安路130号(200032)
实验室主页:https://xuthlab.fudan.edu.cn/
许彤辉,2004年毕业于中国科学院上海生命科学院获得生理学博士学位。2005年-2007年在美国加州大学戴维斯分校(University of California, Davis)从事博士后工作。2007年-2009年在美国加州大学圣克鲁斯分校(University of California, Santa Cruz)从事博士后工作。2010年-2018年月任华中科技大学教授。2018年-2020年任南昌大学教授。2020年至今任复旦大学教授。2010年入选教育部“新世纪优秀人才支持计划”。研究成果以第一作者或通信作者发表在Nature,Nature Neuroscience,Cell Reports,Light: Science & Applications,Neural Plasticity,Frontiers in Neuroanatomy等国际学术期刊。科研方面获得多项国家自然基金资助。
招生专业
动物学
研究方向
1)运动学习的突触和神经环路机制;
2)运动控制系统疾病的发病机制与治疗研究。
主讲课程
《实验动物与动物实验操作技术规程》
《专业外语》
代表性论文(*通讯作者):
1.Chen Z, Xu T*. rAAV2-retro enables extensive and efficient transduction of lower motor neurons following intramuscular injection.Mol Ther Methods Clin Dev. 2019 Nov 21; 17:21-33. doi: 10.1016/j.omtm.2019.11.006. eCollection 2020 Jun 12.
2. Li Z, Chen Z, Fan G, Li A, Yuan J, Xu T*. Cell-Type-Specific Afferent Innervation of the Nucleus Accumbens Core and Shell. Frontiers in Neuroanatomy. 2018 Dct 16; 12:84. doi: 10.3389/fnana.2018.00084. eCollection 2018.
3. Zhao Y, Zhang C, Yu T, Luo Q, Xu T*, Zhu D*. Skull optical clearing window for in vivo imaging of the mouse cortex at synaptic resolution. Light: Science & Applications. 2018 Feb 23;7, 17153; doi:10.1038/lsa.2017.153.
4. Wang S, Zhu J, Xu T*. 17β-estradiol (E2) promotes growth and stability of new dendritic spines via estrogen receptor β pathway in the intact mouse cortex. Brain Research Bulletin. 2017 Dec 27; 137:241-248.
5. Cui Y, Lv G, Jin S, Peng J, Yuan J, He X, Gong H, Xu, F, Xu T *, Li H*. A Central Amygdala-Substantia Innominata Neural Circuitry Encodes Aversive Reinforcement Signals. Cell Reports. 2017 Nov 14;21(7):1770-1782.
6. Xu T, Wang SF, Lalchandani RR, Ding JB*. Motor Learning in Animal Models of Parkinson’s disease: Aberrant Synaptic Plasticity in the Motor Cortex. Movement Disorders. 2017 Mar 25; 32(4):487-497.(Review)
7. Shu Y, Xu T*. Chronic Social Defeat Stress Modulates Dendritic Spines Structural Plasticity in Adult Mouse Frontal Association Cortex. Neural Plasticity. 2017 Jan 18:6207873.
8. Guo L, Xiong H, Kim JI, Wu YW, Lalchandani RR, Cui Y, Shu Y, Xu T *, Ding JB*. Dynamic rewiring of neural circuits in the motor cortex in mouse models of Parkinson’s disease. Nature Neuroscience. 2015 Sep; 18(9):1299-309.(Previewed by: Paolo Calabresi & Massimiliano Di Filippo, Nature Neuroscience.2015 Sep; 8(9):1196-8)
9. Xu T, Yu X, Perlik AJ, Tobin WF, Zweig JA, Tennant K, Jones T, Zuo Y*. Rapid formation and selective stabilization of synapses for enduring memories. Nature. 2009 Dec 17; 462, 915-920. (Previewed by: Noam E. Ziv and Ehud Ahissar, Nature. 2009 Dec 17;462(7275):859-61)
10. Xu T, Nie L, Zhang Y, Mo J, Feng W, Wei D, Petrov E, Calisto LE, Kachar B, Beisel KW, Vazquez AE, Yamoah EN*. Roles of alternative splicing in the functional properties of inner ear-specific KCNQ4 channels. Journal of Biological Chemistry. 2007 Aug; 282(33), 23899-23909.